Pyridine → Benzoic acid, acetylmethyl ester

HRID 1645525

反応式

HRID 1645525 の反応式
N1C=CC=CC=1.C1COCC1.[OH:12][CH2:13][C:14](=[O:16])[CH3:15].[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(OCC)(=O)C>[C:17]([O:12][CH2:13][C:14](=[O:16])[CH3:15])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

6

反応物 4

HCID 1049PyridineHCID 7412Benzoyl chlorideHCID 8028TetrahydrofuranHCID 8299Hydroxyacetone

生成物 1

HCID 23137Benzoic acid, acetylmethyl ester収率 87.8%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a pyridine (25 ml) and THF (10 ml) solution of hydroxyacetone (5 g, 67.5 mmol), benzoyl chloride (12 ml, 103 mmol) was added dropwise at 0° C. in a nitrogen atmosphere and the mixture was stirred for 43 hours at room temperature. Ice was added to the reaction mixture, which was then diluted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, water, and a saline solution, dried over anhydrous sodium sulfate, and concentrated. The obtained crude product was purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate=1/0-1/1 gradient). Desired fractions were concentrated to obtain the title compound (10.56 g, 87.8% yield) as a light yellow oil.

後処理

  1. additionIce was added to the reaction mixture, which
  2. washThe organic layer was washed with 1N hydrochloric acid, water
  3. dry with materiala saline solution, dried over anhydrous sodium sulfate
  4. concentrationconcentrated
  5. customThe obtained crude product
  6. customwas purified by silica gel column chromatography (elution solvent: heptane/ethyl acetate=1/0-1/1 gradient)
  7. concentrationDesired fractions were concentrated

出典と根拠

ORDレコード
ord-3340e11242c74eebae8cb84808027358
出典データセット
uspto-grants-2012_02
特許番号
US08124780B2

関連ノート

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