Formaldehyde → HCID 14751299、化合物

HRID 1651129ノート

反応式

HRID 1651129 の反応式
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([CH:16]=[CH:17][C:18]=1[OH:19])[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:9])([CH3:4])[CH3:3].Cl.[CH3:21][NH:22][CH3:23].[OH-].[Na+].[CH2:26]=O>C(O)C>[CH3:21][N:22]([CH2:26][C:17]1[CH:16]=[C:7]([CH:6]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[C:18]=1[OH:19])[C:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[O:9])[CH3:23]

参加物

6

反応物 4

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 14798Sodium HydroxideHCID 230514754-Benzoyl-2-tert-butylphenol

生成物 1

HCID 14751299HCID 14751299、化合物収率 68.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3-(1,1-Dimethylethyl)-4-hydroxybenzophenone (2.5 g), 1.71 g of dimethylamine hydrochloride, 0.78 g of sodium hydroxide, and 0.68 g of paraformaldehyde were dissolved in 30 ml of ethanol and the mixture was heated to reflux for 16 hours. The ethanol was then evaporate. Water was added to the residue and the crystals which separated out were filtered and recrystallized from 90% ethanol to give 2.1 g of the desire product, m.p. 129° C.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 16 hours
  3. customThe ethanol was then evaporate
  4. additionWater was added to the residue
  5. customthe crystals which separated out
  6. filtrationwere filtered
  7. customrecrystallized from 90% ethanol

出典と根拠

ORDレコード
ord-5eb76259076143588cb276fb41a5f248
出典データセット
uspto-grants-1990_05
特許番号
US04927835

反応ノート

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