Ethyl Acetate → HCID 14770844、化合物

HRID 1651574ノート

反応式

HRID 1651574 の反応式
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][C:11](=[O:14])[CH2:10]2)=[C:4]([F:15])[CH:3]=1.[BH4-].[Na+].[OH-].[Na+].C(OCC)(=O)C>C(O)C.C1COCC1>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([CH:9]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10]2)=[C:4]([F:15])[CH:3]=1

参加物

7

反応物 4

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 14770833HCID 14770833、化合物

生成物 1

HCID 14770844HCID 14770844、化合物収率 72%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To 15.0 g (54.5 mmol) of 3-(4-bromo-2,5-difluorophenyl) cyclopentanone in 150 ml of absolute ethanol and 10 ml of THF was added 2.5 g (65.4 mmol) of sodium borohydride portionwise. The reaction mixture was stirred for 21/2 hours at room temperature, then poured into a mixture of 250 ml of 1.0 N NaOH and 250 ml of ethyl acetate. The organic phase was washed with water, dried (MgSO4), and concentrated. The crude product was chromatographed over silica gel, eluting with 80:20 CHCl3 :EtOAc, to give 10.8 g (72%) of the desired product as a yellow oil.

後処理

  1. washThe organic phase was washed with water
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated
  4. customThe crude product was chromatographed over silica gel
  5. washeluting with 80:20 CHCl3

出典と根拠

ORDレコード
ord-5928a982bb79416ab9f797407590d937
出典データセット
uspto-grants-1990_05
特許番号
US04929613

反応ノート

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