Hydrochloric Acid → 5-(Ethylsulfamoyl)-2-fluorobenzoic acid

To a 5 ml Biotage microwave reaction tube was added 5-(chlorosulfonyl)-2-fluorobenzoic acid (0.4 g, 1.68 mmol) and a Teflon covered magnetic stir-bar followed by 2.5 ml of THF. To the resulting mixture was added 10N aqueous NaOH (0.369 ml, 3.38 mmol) with stirring. After formation of a cloudy suspension, ethylamine (0.838 ml, 1.68 mmol) was added as a 2M solution in THF. The reaction vessel was capped and heated to 110° C. for 1.1 min in a Biotage Initiator 8 microwave set at high absorbance. Reaction mixture was then diluted with 4 ml acetonitrile and acidified with 6M aqueous HCl (0.670 ml, 4.02 mmol). Water was removed from the mixture by adding excess anhydrous Na2SO4 and subsequent filtration. The filtered was washed with acetonitrile and DMF. The combined filtrates were concentrated with rotary evaporation, yielding the crude 5-[(ethylamino)sulfonyl]-2-fluorobenzoic acid.

1. customTo a 5 ml Biotage microwave reaction tube
2. customThe reaction vessel was capped
3. customReaction mixture
4. customWater was removed from the mixture
5. additionby adding excess
6. filtrationanhydrous Na2SO4 and subsequent filtration
7. washThe filtered was washed with acetonitrile and DMF
8. concentrationThe combined filtrates were concentrated with rotary evaporation

ORDレコード

ord-64d2579829bf47848507b9026bbedf20

出典データセット

uspto-grants-2011_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08044075B2