2-(3-Chloropropyl)-2-methyl-1,3-dioxolane → 2-(3-Bromopropyl)-2-methyl-1,3-dioxolane
反応式
[CH2:1]1[O:10][C:4]([CH2:6][CH2:7][CH2:8]Cl)([CH3:5])[O:3][CH2:2]1.[Br-:11].[Li+].C(N(C(C)C)CC)(C)C>O1CCCC1>[CH2:1]1[O:10][C:4]([CH2:6][CH2:7][CH2:8][Br:11])([CH3:5])[O:3][CH2:2]1参加物
5
実験手順
4.0 Parts of 5-chloro-2-pentanone ethylene ketal is mixed with 9.0 parts of lithium bromide and 2.0 parts of diisopropylethylamine in 30 parts by volume of tetrahydrofuran which has been distilled from lithium aluminum hydride. The mixture is refluxed under nitrogen for 48 hours, cooled and poured into a mixture of ether and water for extraction. The ether layer is washed twice with water, then with 1 N hydrochloric acid and then twice again with water. The ether layer is then dried over sodium sulfate and evaporated under reduced pressure to give 5-bromo-2-pentanone ethylene ketal having the formula ##STR6##
後処理
- distillationhas been distilled from lithium aluminum hydride
- temperatureThe mixture is refluxed under nitrogen for 48 hours
- temperaturecooled
- additionpoured into a mixture of ether and water for extraction
- washThe ether layer is washed twice with water
- dry with materialThe ether layer is then dried over sodium sulfate
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-5af8367d6c97437fbedeab8b39088a6f
- 出典データセット
- uspto-grants-1981_06
- 特許番号
- US04271314
反応ノート
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