Tetrahydrofuran → 3-Chloro-4-methoxybenzoyl chloride

HRID 1683838

反応式

HRID 1683838 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5](O)=[O:6].O1CCCC1.C(Cl)(=O)C([Cl:21])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([Cl:21])=[O:6]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 1699823-Chloro-p-anisic acid

生成物 1

HCID 47692993-Chloro-4-methoxybenzoyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A stirred solution of 0.22 gram (0.0012 mole) of 3-chloro-4-methoxybenzoic acid in a small amount of tetrahydrofuran and chloroform was cooled to 0° C., and 0.12 mL (0.0014 mole) of oxalyl chloride was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature, where it was stirred for about 3.5 hours. After this time the reaction mixture was concentrated under reduced pressure, yielding 3-chloro-4-methoxybenzoyl chloride, which was dissolved in a small amount of tetrahydrofuran for later use.

後処理

  1. additionUpon completion of addition
  2. concentrationAfter this time the reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-0486d7e71bd341848c7455704c1e7c5c
出典データセット
uspto-grants-1997_06
特許番号
US05639763

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