Trityl chloride → HCID 70604455、化合物

HRID 1730313ノート

反応式

HRID 1730313 の反応式
[C:1](Cl)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][C:22]1([CH3:34])[S:26][C@@H:25]2[C@H:27]([NH2:30])[C:28](=[O:29])[N:24]2[C@H:23]1[C:31](O)=O.C([N:37](CC)CC)C>C(Cl)(Cl)Cl>[C:2]1([C:1]([NH:30][CH:27]2[C:28](=[O:29])[N:24]3[CH:23]([C:31]#[N:37])[C:22]([CH3:34])([CH3:21])[S:26][C@H:25]23)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 110826-Aminopenicillanic acid

生成物 1

HCID 70604455HCID 70604455、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Tritylchloride (61.2 g., 0.22 mole) is added to a mixture of 6-aminopenicillanic acid (43.3 g., 0.20 mole) and triethylamine (5.56 ml.)in chloroform (300 ml.) at about 5° C. The somewhat exothermic reaction is stirred and allowed to rise gradually to room temperature. It is stirred at room temperature for three days. Evaporation of the reactionmixture affords the title product which is used without purification.

後処理

  1. customat about 5° C
  2. customThe somewhat exothermic reaction
  3. customto rise gradually to room temperature
  4. stirringIt is stirred at room temperature for three days
  5. customEvaporation of the reactionmixture

出典と根拠

ORDレコード
ord-60ee0b7ffdb844f98d0b8cddf91f57ec
出典データセット
uspto-grants-1976_11
特許番号
US03992394

反応ノート

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