Water → 1-Methyl-5-phenyl-1H-imidazol-2-ylamine
反応式
[CH3:1][NH:2][C:3]1[N:8]=CC=C[N:4]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=O.O.NN.O>C(#N)C>[CH3:1][N:2]1[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:10][N:4]=[C:3]1[NH2:8]参加物
6
反応条件
- 温度
- 130 °C
実験手順
To a microwave vial containing a solution of N-methylpyrimidin-2-amine (290 mg, 2.7 mmol) in acetonitrile (5 mL) is added 2-bromo-1-phenylethanone (714 mg, 3.6 mmol). The vial is sealed and heated in a microwave reactor at 130° C. for 20 minutes and is cooled to room temperature. The mixture is treated with hydrazine hydrate (0.65 mL, 13.3 mmol) and is then heated in a microwave reactor at 100° C. for 5 minutes. The reaction is poured into water (30 mL) and filtered to afford the title compound (192 mg, 42%) as a solid.
後処理
- customThe vial is sealed
- temperatureis cooled to room temperature
- temperatureis then heated in a microwave reactor at 100° C. for 5 minutes
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-20e88d400cb54887ad9f0d7f196b5f93
- 出典データセット
- uspto-grants-2015_10
- 特許番号
- US09150577B2
反応ノート
読み込み中…