Tetrahydrofuran → HCID 67263064、化合物

反応式

[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14](O)=[O:15])[CH2:6][CH2:5]2.C1N=[CH:22][N:21](C(N2C=NC=C2)=O)[CH:20]=1.C1COCC1>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([N:21]([CH3:22])[CH3:20])=[O:15])[CH2:6][CH2:5]2

参加物

反応物 3

HCID 8028Tetrahydrofuran

HCID 40634Trolox

HCID 682631,1'-Carbonyldiimidazole

生成物 1

HCID 67263064HCID 67263064、化合物収率 73.9%

実験手順

Following the amide coupling procedure described in protocol A, 504 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (2.01 mmol), 361 mg CDI (2.23 mmol) and 1.1 mL of a 2.0 M solution of NN-dimethylamine in THF (2.2 mmol) produced 412 mg of 6-hydroxy-N,N,2,5,7,8-hexamethylchroman-2-carboxamide as amorphous powder.

出典と根拠

ORDレコード: ord-fac1e13913694e1f8343439de04bf8e7
出典データセット: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09169196B2

反応ノート

読み込み中…

参加物