4-Methylmorpholine → N-[4-(Hydroxymethyl)phenyl]-N-methylacetamide

HRID 1757452ノート

反応式

HRID 1757452 の反応式
[C:1]([N:4]([C:6]1[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][CH:7]=1)[CH3:5])(=[O:3])[CH3:2].CN1CCOCC1.ClC(OCC(C)C)=O.[BH4-].[Na+]>O.CN(C=O)C.COCCOC>[C:1]([N:4]([C:6]1[CH:14]=[CH:13][C:9]([CH2:10][OH:11])=[CH:8][CH:7]=1)[CH3:5])(=[O:3])[CH3:2]

参加物

8

反応物 4

HCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 2834714-(N-methylacetamido)benzoic acidHCID 4311764Sodium borohydride

生成物 1

HCID 54439979N-[4-(Hydroxymethyl)phenyl]-N-methylacetamide

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 80711,2-Dimethoxyethane溶媒

反応条件

温度
-20 °C

実験手順

An oven dried flask, under nitrogen flow, was charged with a stir bar, 4-(N-acetyl-N-methyl-amino)benzoic acid (1.0 g, 5.18 mmol), prepared as in step7, anhydrous DME (10.3 mL), and anhydrous DMF (3.0 mL). The resulting solution was cooled to -20° C., and 4-methylmorpholine (0.60 mL, 5.4 mmol) and isobutyl chloroformate (0.70 mL, 5.4 mmol) were added sequentially via syringe. The reaction mixture was stirred under N2 at -20° C. for 1 hour. The resultant yellow mixture was filtered and the precipitate washed with DME (2×, ~1 mL). The combined filtrate and washings were cooled to 0° C. and sodium borohydride (800 mg, 21.1 mmol) dissolved in water (2.0 mL) was added dropwise. The reaction was stirred at 0° C. for 15 min. and quenched with saturated aqueous ammonium chloride. The resulting mixture was partitionedbetween ethyl acetate and brine. The combined organic layers were dried (MgSO 4), filtered and concentrated in vacuo to give an oil. Purification by flash chromatography on silica gel (90% ethyl acetate/hexane) provided 4-(N-acetyl-N-methyl-amino)benzyl alcohol as a colorless oil which solidified on standing. Recrystallization from hexane provided the alcohol as a colorless solid (543.0 mg, 58.5%). 1H NMR (300 MHz, CDCl3) d 7.45 (2H, d, J=8.5 Hz), 7.18 (2H, d, J=8.5 Hz), 4.75 (2H, s), 3.27 (3H, s), 1.90 (3H, br s). MS m/e 180 (M+H)+, 197 (M+NH4)+.

後処理

  1. customAn oven dried flask
  2. additionunder nitrogen flow, was charged with a stir bar
  3. filtrationThe resultant yellow mixture was filtered
  4. washthe precipitate washed with DME (2×, ~1 mL)
  5. temperatureThe combined filtrate and washings were cooled to 0° C.
  6. additionwas added dropwise
  7. stirringThe reaction was stirred at 0° C. for 15 min.
  8. customquenched with saturated aqueous ammonium chloride
  9. dry with materialThe combined organic layers were dried (MgSO 4)
  10. filtrationfiltered
  11. concentrationconcentrated in vacuo
  12. customto give an oil
  13. customPurification by flash chromatography on silica gel (90% ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-e14a4690f355456cb6dc38df1d244fbb
出典データセット
uspto-grants-1995_08
特許番号
US05446062

反応ノート

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