Sodium Carbonate → 4-(1,2,3-thiadiazol-4-yl)pyridine

HRID 1762689ノート

反応式

HRID 1762689 の反応式
[C:1](=[N:9][NH:10]C(N)=O)([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2].[S:14](Cl)(Cl)=O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[S:14]1[CH:2]=[C:1]([C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)[N:9]=[N:10]1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 24386Thionyl ChlorideHCID 2755736HCID 2755736、化合物

生成物 1

HCID 14718104-(1,2,3-thiadiazol-4-yl)pyridine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

16.8 g of 4-acetylpyridine semicarbazone was added to 47 ml of thionyl chloride under ice-cooling, and, after allowing to warm to room temperature, the mixture was stirred for 1 hour. 200 ml of chloroform was added to the reaction mixture, and the resulting mixture was added dropwise to an aqueous solution of sodium carbonate cooled with ice. The chloroform layer was separated, washed with water, dried and concentrated to obtain 3.4 g of 4-(1,2,3-thiadiazol-4-yl)pyridine. Melting point: 121°-123° C.

後処理

  1. temperaturecooling
  2. temperaturecooled with ice
  3. customThe chloroform layer was separated
  4. washwashed with water
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-19d4b9ad136843178a319c19c55eddd8
出典データセット
uspto-grants-1989_05
特許番号
US04833242

反応ノート

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