Benzyl Alcohol → HCID 52463841、化合物

HRID 1777752

反応式

HRID 1777752 の反応式
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8][C:9]([OH:11])=[O:10])[N:3]=1.[CH2:12](O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1CCC(N=C=NC2CCCCC2)CC1>CN(C1C=CN=CC=1)C.CC#N>[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8][C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[N:3]=1

参加物

6

反応物 3

HCID 244Benzyl AlcoholHCID 10868DicyclohexylcarbodiimideHCID 572875(3,5-Dimethyl-1H-pyrazol-1-yl)acetic acid

生成物 1

HCID 52463841HCID 52463841、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6342Acetonitrile溶媒

実験手順

A mixture of (3,5-dimethyl-1H-pyrazol-1-yl)acetic acid (600 mg), benzyl alcohol (0.402 mL), DMAP (194 mg) and DCC (802 mg) in MeCN (40 mL) was stirred at RT overnight. The suspension was filtered off and the resulting solution was evaporated to dryness. The residue was purified by CC (Hept/EA 7/3) to afford benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate (460 mg, white solid). LC-MS (B): tR=0.80 min; [M+H]+: 245.18.

後処理

  1. filtrationThe suspension was filtered off
  2. customthe resulting solution was evaporated to dryness
  3. customThe residue was purified by CC (Hept/EA 7/3)

出典と根拠

ORDレコード
ord-bd5d153c9de04fad9880e8f06258083d
出典データセット
uspto-grants-2016_02
特許番号
US09266876B2

関連ノート

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