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Benzenesulfonamide → n-(2-Hydroxy-indan-1-yl)-2-[4-(6-methoxy-3-phenyl-naphthalen-1-yloxy)-2-(1-phenylmethanesulfonylaminocarbonyl-2-vinyl-cyclopropyl)-pyrrolidin-1-yl]-3,3-dimethyl-butyramide

HRID 1822434
ノート
印刷プレビュー

反応式

HRID 1822434 の反応式
[OH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[NH:11][C:12]([CH:14]([N:19]1[CH2:23][CH:22]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:35][CH3:36])=[CH:32][CH:33]=3)[CH:28]=[C:27]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[CH:26]=2)[CH2:21][CH:20]1[C:43]1([C:48](O)=[O:49])[CH2:45][CH:44]1[CH:46]=[CH2:47])[C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13].[C:51]1([S:57]([NH2:60])(=[O:59])=[O:58])C=CC=CC=1.C(N([CH:67]([CH3:69])[CH3:68])CC)(C)C.[CH2:70]1[CH2:74]N([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)C[CH2:71]1.F[P-](F)(F)(F)(F)F.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[OH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]1[NH:11][C:12](=[O:13])[CH:14]([N:19]1[CH2:23][CH:22]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:35][CH3:36])=[CH:32][CH:33]=3)[CH:28]=[C:27]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[CH:26]=2)[CH2:21][CH:20]1[C:43]1([C:48]([NH:60][S:57]([CH2:51][C:68]2[CH:67]=[CH:69][CH:74]=[CH:70][CH:71]=2)(=[O:59])=[O:58])=[O:49])[CH2:45][CH:44]1[CH:46]=[CH2:47])[C:15]([CH3:16])([CH3:18])[CH3:17]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 7370BenzenesulfonamideHCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 2724699PyBOPHCID 68493461HCID 68493461、化合物

生成物 1

HCID 68493430
n-(2-Hydroxy-indan-1-yl)-2-[4-(6-methoxy-3-phenyl-naphthalen-1-yloxy)-2-(1-phenylmethanesulfonylaminocarbonyl-2-vinyl-cyclopropyl)-pyrrolidin-1-yl]-3,3-dimethyl-butyramide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To solution of 14 (25 mg, 0.033 mmol) in chloroform (1 mL) was added benzenesulfonamide (10.5 mg, 0.066 mmol) followed by diisopropylethylamine (34 μL, 0.197 mmol). The solution was stirred at RT for 10 min and then at −20° C. for 30 min. PyBOP (76 mg, 0.13 mmol) was then added as a solid. The solution was kept at −20° C. for 48 hours. The solution was then poured into aqueous NaHCO3 (sat.) and washed with water. The organic layer was dried, concentrated and subjected to purification by HPLC, affording the title compound as a white solid.

後処理

  1. waitat −20° C. for 30 min
  2. waitThe solution was kept at −20° C. for 48 hours
  3. washwashed with water
  4. customThe organic layer was dried
  5. concentrationconcentrated
  6. customsubjected to purification by HPLC

出典と根拠

ORDレコード
ord-ec00197691184e7fbdb8f315c7ccf945
出典データセット
uspto-grants-2009_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07608590B2

反応ノート

読み込み中…

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