Acryloyl chloride → N-[4-(2-Morpholin-4-yl-ethylsulfamoyl)-phenyl]-acrylamide

HRID 1841952

反応式

HRID 1841952 の反応式
C(N(C(C)C)CC)(C)C.[NH2:10][C:11]1[CH:16]=[CH:15][C:14]([S:17]([NH:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)(=[O:19])=[O:18])=[CH:13][CH:12]=1.[C:29](Cl)(=[O:32])[CH:30]=[CH2:31]>C1COCC1>[N:23]1([CH2:22][CH2:21][NH:20][S:17]([C:14]2[CH:13]=[CH:12][C:11]([NH:10][C:29](=[O:32])[CH:30]=[CH2:31])=[CH:16][CH:15]=2)(=[O:19])=[O:18])[CH2:24][CH2:25][O:26][CH2:27][CH2:28]1

参加物

5

反応物 3

HCID 13140Acryloyl chlorideHCID 81531DiisopropylethylamineHCID 120569Benzenesulfonamide, 4-amino-N-[2-(4-morpholinyl)ethyl]-

生成物 1

HCID 67194942N-[4-(2-Morpholin-4-yl-ethylsulfamoyl)-phenyl]-acrylamide収率 5.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Diisopropylethylamine (0.09 ml, 0.5 mmol) was added in one portion to a stirred solution of 4-amino-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide (0.1 g, 0.35 mmol) in THF (3 ml) at room temperature. To this mixture was added acryloyl chloride (0.03 ml, 0.38 mmol) in one portion and the mixture was stirred at room temperature under a nitrogen atmosphere for 1 hour. After this time, the mixture was concentrated under vacuum and the resulting residue purified by Prep HPLC to give the title compound (6 mg, 5% yield) as a white solid.

後処理

  1. concentrationAfter this time, the mixture was concentrated under vacuum
  2. customthe resulting residue purified by Prep HPLC

出典と根拠

ORDレコード
ord-fbc6602e838844ea8049e8f1cc4695df
出典データセット
uspto-grants-2015_02
特許番号
US08946197B2

関連ノート

読み込み中…