Pyridine → 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide

HRID 18509

反応式

HRID 18509 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.N1C=CC=CC=1.[Br:15][CH2:16][C:17](Br)=[O:18]>C1(C)C=CC=CC=1>[Br:15][CH2:16][C:17]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)=[O:18]

参加物

5

反応物 3

HCID 1049PyridineHCID 61147Bromoacetyl bromideHCID 661742-Amino-5-chloropyridine

生成物 1

HCID 34211102-Bromo-N-(5-chloro-2-pyridinyl)acetamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.

後処理

  1. additionwere added dropwise under ice cooling
  2. customAfter 2 h the precipitate was isolated by filtration
  3. customrecrystallized from toluene
  4. customto yield a white solid

出典と根拠

ORDレコード
ord-31ec5a5ff49240e090abf794e19ea941
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

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