Pyridine → 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.N1C=CC=CC=1.[Br:15][CH2:16][C:17](Br)=[O:18]>C1(C)C=CC=CC=1>[Br:15][CH2:16][C:17]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)=[O:18]参加物
5
実験手順
To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.
後処理
- additionwere added dropwise under ice cooling
- customAfter 2 h the precipitate was isolated by filtration
- customrecrystallized from toluene
- customto yield a white solid
出典と根拠
- ORDレコード
- ord-31ec5a5ff49240e090abf794e19ea941
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741341B2
反応ノート
読み込み中…