Acetic Acid → (1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy-

HRID 1856512

反応式

HRID 1856512 の反応式
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][C:4]([C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+].[BH4-].[Na+].C(O)(=O)C>O>[OH:8][CH:7]([C:4]1[CH:5]=[CH:6][C:1]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:2][CH:3]=1)[CH2:9][CH2:10][C:11]([OH:13])=[O:12]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 3335FenbufenHCID 14798Sodium HydroxideHCID 4311764Sodium borohydride

生成物 1

HCID 16072199(1,1'-Biphenyl)-4-butanoic acid, gamma-hydroxy-

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 25.4 g. portion of 3-(4-biphenylylcarbonyl)propionic acid is dissolved in 2 liters of water made alkaline with sodium hydroxide. A 37.8 g. portion of sodium borohydride is added and the mixture is stirred for 2 hours. The suspension is then slowly poured into 100 ml. of glacial acetic acid. The mixture is cooled and the resulting solid is filtered, washed with water and dried giving the desired product, m.p. 139°-140° C.

後処理

  1. additionThe suspension is then slowly poured into 100 ml
  2. temperatureThe mixture is cooled
  3. filtrationthe resulting solid is filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-683b6ab37ab6474ab8171af01f918ae9
出典データセット
uspto-grants-1980_08
特許番号
US04219668

関連ノート

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