Dimethylformamide → 4-chloro-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxylic acid

nBuLi (1.27 mL of a 1.57 M solution in hexanes, 2.00 mmol) was added dropwise to a solution of 2-bromo-4,5-dichloro-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole (0.69 g, 2.0 mmol) in THF (40 mL) at −78° C. under N2. The reaction mixture was stirred for 20 min and TMSCl (0.25 mL, 2.00 mmol) was added dropwise. The cooling bath was removed and the reaction mixture was allowed to warm to RT. After 4 h at RT, the solution was cooled to −78° C. and nBuLi (1.27 mL of a 1.57 M solution in hexanes, 2.00 mmol) was added dropwise. After 30 min, DMF (1.0 mL, 12.91 mmol) was added and the reaction was stirred at RT for 20 min. Saturated aqueous NH4Cl solution was added to the reaction and extracted with EtOAc. The organic phase was dried (Na2SO4), filtered, and purified by silica gel chromatography (0-30% EtOAc/hexanes) to afford a mixture of two compounds. THF (5 mL) was added followed by tBuOH (1.21 mL) and 2-methyl-butene (9.8 mL of a 2M solution in THF, 19.5 mmol). A solution of NaClO2 (1.4 g, 15.6 mmol) and NaH2PO4.H2O (1.29 g, 9.4 mmol) in water (4 mL) was added and the solution was stirred at RT overnight. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The organic layer was separated, dried over Na2SO4, filtered and concentrated to give 0.43 g (77%) of the title compound as a pale yellow oil. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.43 (br. s., 1H), 8.10 (s, 1H), 5.60 (s, 2 H), 3.48 (t, 2H), 0.82 (t, 2H), −0.06 (s, 9H).

1. customThe cooling bath was removed
2. waitAfter 4 h at RT
3. temperaturethe solution was cooled to −78° C.
4. additionnBuLi (1.27 mL of a 1.57 M solution in hexanes, 2.00 mmol) was added dropwise
5. waitAfter 30 min
6. stirringthe reaction was stirred at RT for 20 min
7. extractionextracted with EtOAc
8. dry with materialThe organic phase was dried (Na2SO4)
9. filtrationfiltered
10. custompurified by silica gel chromatography (0-30% EtOAc/hexanes)
11. customto afford
12. additiona mixture of two compounds
13. stirringthe solution was stirred at RT overnight
14. customThe organic layer was separated
15. extractionthe aqueous layer was extracted with ethyl acetate
16. customThe organic layer was separated
17. dry with materialdried over Na2SO4
18. filtrationfiltered
19. concentrationconcentrated

ORDレコード

ord-a5a133a3b9b44b0aaca84e9180cb6c47

出典データセット

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08304419B2