Oxygen → 4-Formylbenzoic acid

HRID 18852

反応式

HRID 18852 の反応式
CC1C=CC(C(O)=O)=CC=1.C(ON1C(=O)C2=CC=CC=C2C1=O)(=O)C.O=O.[C:28](O)(=[O:38])[C:29]1[CH:37]=[CH:36][C:32]([C:33]([OH:35])=[O:34])=[CH:31][CH:30]=1>[Ti].O.O.O.O.C([O-])(=O)C.[Co+2].C([O-])(=O)C.O.O.O.O.C([O-])(=O)C.[Mn+2].C([O-])(=O)C.C(O)(=O)C>[C:33]([C:32]1[CH:36]=[CH:37][C:29]([CH:28]=[O:38])=[CH:30][CH:31]=1)([OH:35])=[O:34]

参加物

9

反応物 4

HCID 977OxygenHCID 7470P-Toluic Acid2 回HCID 7489Terephthalic AcidHCID 2655661,3-dioxo-2,3-dihydro-1H-isoindol-2-yl acetate

生成物 1

HCID 120884-Formylbenzoic acid収率 74.4%

試薬・触媒・溶媒 4

HCID 23963Titanium触媒HCID 61372Cobalt(II) acetate tetrahydrate触媒HCID 93021Manganese acetate tetrahydrate触媒HCID 176Acetic Acid溶媒

実験手順

In a 500-ml titanium autoclave, 15.36 g (0.113 mol) of p-toluic acid, 0.232 g (1.13 mmol) of N-acetoxyphthalimide, 0.112 g (0.45 mmol) of cobalt(II) acetate tetrahydrate, 0.277 g (1.13 mmol) of manganese(II) acetate tetrahydrate and 107 g of acetic acid were placed, the resulting mixture was stirred at 170° C. in an atmosphere of a mixture of oxygen and nitrogen gases (1:1) [4 MPa (gauge pressure)] for 1 hour and thereby yielded terephthalic acid in a yield of 74.4% with a conversion from p-toluic acid of 77.5%. A small amount of 4-carboxybenzaldehyde was by-produced.

出典と根拠

ORDレコード
ord-3500e43be4764fef9521e7c14135bdb9
出典データセット
uspto-grants-2010_06
特許番号
US07741514B2

関連ノート

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