Sodium Iodide → HCID 70424592、化合物

反応式

[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1COC)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:5])C.[I-:22].[Na+].[CH3:24][Si](C)(C)Cl>C(#N)C>[CH3:1][O:3][C:4]([C:6]1[N:7]=[C:8]([CH3:24])[C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[I:22])=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:5]

参加物

反応条件

温度: 60 °C

実験手順

A suspension of 1.5 g of 4-methoxymethyl-beta-carboline-3-carboxylic-acid-ethylester, 20 ml of acetonitrile, 3.1 g of sodium iodide and 2.7 ml of trimethylchlorosilane is stirred at 60° C. for 2 h. After cooling, it is poured into ice water and extracted with ethyl acetate. The extracts are washed with saturated sodium thiosulfate solution, dried and concentrated. 1.65 g of 4-iodo-methyl-beta-carboline-3-carboxylic-acid-methylester with a m.p. of 280°-286° C. is obtained.