Trimethylamine → (-)-Carnitine

HRID 1920278

反応式

HRID 1920278 の反応式
[OH-].[Na+].[CH3:3][N:4]([CH3:6])[CH3:5].Cl[CH2:8][C@H:9]([OH:16])[CH2:10][C:11]([O:13]CC)=[O:12]>O>[OH:16][C@H:9]([CH2:10][C:11](=[O:12])[O-:13])[CH2:8][N+:4]([CH3:6])([CH3:5])[CH3:3]

参加物

5

反応物 3

HCID 1146TrimethylamineHCID 14798Sodium HydroxideHCID 27344454-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-

生成物 1

HCID 10917(-)-Carnitine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

Sodium hydroxide (17.6 g, 0.44 mol, ca. 2 eq.) was dissolved in water (240 g). Aqueous tri-methylamine (25%, 61.3 g, ca. 1.2 eq.) was added with cooling. The resulting mixture was cooled to 0° C. and ethyl (R)-4-chloro-3-hydroxybutyrate (content 100%, 36 g, 0.216 mol) was added dropwise within 3 h to the stirred reaction mixture. After one additional hour at 0° C. the reaction mixture was warmed to +20° C. and analyzed by HPLC

後処理

  1. temperaturewith cooling
  2. temperatureAfter one additional hour at 0° C. the reaction mixture was warmed to +20° C.

出典と根拠

ORDレコード
ord-5e283c3900a6496c954386c8f9d78056
出典データセット
uspto-grants-2012_05
特許番号
US08168823B2

関連ノート

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