Water → 2-Fluorofluorene

HRID 1935320

反応式

HRID 1935320 の反応式
[F:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=O)[C:4]=2[CH:3]=1.O.NN.O>C(O)CO>[F:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH2:5][C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 960169H-Fluoren-9-one, 2-fluoro-

生成物 1

HCID 2411322-Fluorofluorene

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

反応条件

温度
180 °C

実験手順

2-Fluoro-9-fluorenone, 20 (1.78 gms, 8.9 mmol) was dissolved in ethylene glycol(60 mL) under a nitrogen atmosphere. Hydrazine hydrate(1.8 mL) was added and the mixture was heated at 180° C. for two hours. The mixture was then cooled and poured into water. The aqueous layer was extracted with ethyl acetate and the organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated to yield the title compound.

後処理

  1. temperatureThe mixture was then cooled
  2. extractionThe aqueous layer was extracted with ethyl acetate
  3. washthe organic layer was washed with brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-88062313c62a46fcb049910b9140c534
出典データセット
uspto-grants-2002_05
特許番号
US06387893B1

関連ノート

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