[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:12][CH3:13])=[C:7]([CH:11]=1)[C:8]([OH:10])=O)#[N:2].C(Cl)(=O)C(Cl)=O.[N:20]1([CH2:26][C:27]2[CH:41]=[CH:40][C:30]3[NH:31][C:32]([C:34]4[C:38]([NH2:39])=[CH:37][NH:36][N:35]=4)=[N:33][C:29]=3[CH:28]=2)[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1.C(C1C=CC(OC)=C(C=1)C(Cl)=O)#N.C(N(C(C)C)CC)(C)C>C(Cl)Cl.CN(C=O)C.C1COCC1>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:12][CH3:13])=[C:7]([CH:11]=1)[C:8]([NH:39][C:38]1[C:34]([C:32]2[NH:31][C:30]3[CH:40]=[CH:41][C:27]([CH2:26][N:20]4[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)=[CH:28][C:29]=3[N:33]=2)=[N:35][NH:36][CH:37]=1)=[O:10])#[N:2]5-Cyano-2-methoxy-benzoic acid (Example 1F) (40 mg, 0.22 mmol) was dissolved in DCM (5 ml) and oxalyl chloride (34.4 mg, 0.264 mmol) was then added drop wise followed by DMF (1 drop). The reaction mixture was stirred at ambient temperature for 1 hour, reduced in vacuo, then re-evaporated using toluene (×2). A mixture of 3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-ylamine (100 mg, 0.33 mmol), 5-cyano-2-methoxy-benzoyl chloride and diisopropylethylamine (1.83 μl, 0.9 mmol) in THF (5 ml) was stirred at 0° C. and then allowed to warm to room temperature over 2 hours. The reaction mixture was then concentrated in vacuo. The residue was purified by flash column chromatography SiO2, 5-7% MeOH-DCM] to give 5-cyano-2-methoxy-N-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-benzamide (12 mg). (LC/MS Acidic: Rt 2.02 min [M−H]+458).
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