Methyl iodide → Benzyl [(1R)-2-methoxy-1-methylethyl]carbamate
反応式
[OH:1][CH2:2][C@H:3]([NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:4].[CH3:16]I>C(#N)C.[Ag]=O>[CH3:16][O:1][CH2:2][C@H:3]([NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:4]参加物
5
実験手順
To a solution of benzyl [(1R)-2-hydroxy-1-methylethyl]carbamate (0.5 g, 2.38 mmol) in acetonitrile (20 mL), silver oxide (3.8 g, 13.09 mmol) is added followed by the addition of methyl iodide (1.94 mL, 23.8 mmol). The resultant mixture was stirred overnight at room temperature. The insoluble salt was filtered off and the filtrate was concentrated. The residue was flashed using silica and Ethyl acetate/hexanes system as eluent to give the desired product as clear oil (0.38 g).
後処理
- filtrationThe insoluble salt was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-623a13dc66014028b2ce2f1c8414dec1
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399489B2
反応ノート
読み込み中…