Lithium Bromide → (4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilane

HRID 1953383ノート

反応式

HRID 1953383 の反応式
FC(F)(F)C(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])=[CH:9][CH:8]=1)=O.[Br-:23].[Li+]>C1COCC1.C(#N)C>[Si:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][Br:23])=[CH:8][CH:9]=1)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15]

参加物

5

反応物 2

HCID 82050Lithium BromideHCID 99970054-{(t-Butyldimethylsilyl)oxy}benzyl trifluoroacetate

生成物 1

HCID 10380115(4-(Bromomethyl)phenoxy)(tert-butyl)dimethylsilane収率 88%

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The benzyl trifluoroacetate 8 (17.9 g) was dissolved in dry THF, and dry lithium bromide (5.06 g) was added with stirring. The mixture was refluxed overnight, cooled, diluted with acetonitrile, and extracted three times with hexane. The hexane layers were combined, dried, filtered, and concentrated, thereby leaving the product 10 as a white oil in 88% yield.

後処理

  1. temperatureThe mixture was refluxed overnight
  2. temperaturecooled
  3. extractionextracted three times with hexane
  4. customdried
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-caea78892fa840b9b949dda17bcf4585
出典データセット
uspto-grants-2000_09
特許番号
US06117845

反応ノート

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