Iodoethane → dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-(ethylamino)ethylphosphonate

HRID 1953780ノート

反応式

HRID 1953780 の反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16][CH3:17])[C:10]([O:14][CH3:15])=[N:11]2)=[C:6]([CH2:18][NH:19][CH:20]([P:22](=[O:27])([O:25][CH3:26])[O:23][CH3:24])[CH3:21])[CH:5]=1)([O-:3])=[O:2].[CH2:28](I)[CH3:29].C(N(C(C)C)CC)(C)C>C(#N)C>[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([N:8]=[C:9]([O:16][CH3:17])[C:10]([O:14][CH3:15])=[N:11]2)=[C:6]([CH2:18][N:19]([CH2:28][CH3:29])[CH:20]([P:22](=[O:27])([O:23][CH3:24])[O:25][CH3:26])[CH3:21])[CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 6340IodoethaneHCID 81531DiisopropylethylamineHCID 23297975Dimethyl N-(7-Nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-aminoethylphosphonate

生成物 1

HCID 23298022dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-alpha-(ethylamino)ethylphosphonate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

300 mg (0.75 mmol) of dimethyl N-(7-nitro-2,3-dimethoxyquinoxalin-5-ylmethyl)-α-aminoethylphosphonate, 0.482 ml (8 eq.) of ethyl iodide and 1.4 ml (11 eq.) of diisopropylethylamine are stirred at 700 for 24 hours in 10 ml of acetonitrile. The reaction mixture is evaporated and the residue is stirred in diethyl ether. The solid is filtered off, washed with diethyl ether and the filtrate is evaporated. The title compound is obtained as a brownish oil.

後処理

  1. customThe reaction mixture is evaporated
  2. filtrationThe solid is filtered off
  3. washwashed with diethyl ether
  4. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-a2966ee69d99414abdb20a20e52a4394
出典データセット
uspto-grants-2000_09
特許番号
US06117873

反応ノート

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