Ammonia → 6-Aminohexanenitrile

HRID 1954488ノート

反応式

HRID 1954488 の反応式
[CH:1]([CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[N:8])=O.[OH-].[Li+].[NH3:11]>[H][H].[Pd]>[NH2:11][CH2:1][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[N:8].[NH2:11][CH2:1][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH2:8]

参加物

7

反応物 3

HCID 222AmmoniaHCID 3939Lithium HydroxideHCID 110406526-Oxohexanenitrile

生成物 2

HCID 16402HexamethylenediamineHCID 170796-Aminohexanenitrile収率 59.01%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 178418361HCID 178418361、化合物溶媒2 回

反応条件

温度
100 °C

実験手順

In the autoclave described in Example 1 there were placed 20 g of 5-formylvaleronitrile and 3 g of Pd (2%) on Al2O3 powder and 0.41 g of lithium hydroxide under protective gas (argon). The autoclave was then sealed and 140 ml of NH3 were forced in. The mixture was stirred using a magnetic stirrer and was heated to 100° C. and the overall pressure raised to 80 bar by forcing in hydrogen and then kept at this value by continuous replenishment with hydrogen. After a period of 23 hours the autoclave was depressurized and the hydrogenation effluent analyzed by gas chromatography. The products formed comprised 59.01% of 6-aminocapronitrile and 5.1% of hexamethylene diamine (conversion 100%).

後処理

  1. customThe autoclave was then sealed
  2. temperaturethe overall pressure raised to 80 bar

出典と根拠

ORDレコード
ord-2f3483a361a44544a596ba54b00fbf7b
出典データセット
uspto-grants-2000_09
特許番号
US06121481

反応ノート

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