Sodium Hydroxide → 2-Methoxypyridin-4-amine

HRID 1974832

反応式

HRID 1974832 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][N+:4]=1[O-].[OH-].[Na+]>C(O)(=O)C.[Fe]>[NH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 5792072-Methoxy-4-nitropyridine-n-oxide

生成物 1

HCID 2808912-Methoxypyridin-4-amine

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 176Acetic Acid溶媒

反応条件

温度
100 °C

実験手順

A mixture of 6.3 g of 2-methoxy-4-nitropyridine N-oxide and 12.6 g of iron powder in 150 ml of acetic acid is heated for 1 hour at 100° C. After cooling, sodium hydroxide is added, the mixture is then filtered and the material on the filter is washed with water. The aqueous phase is extracted with ethyl ether. After drying and concentration, 3.6 g of an oil are recovered which crystallizes to a white solid.

後処理

  1. temperatureAfter cooling
  2. filtrationthe mixture is then filtered
  3. washthe material on the filter is washed with water
  4. extractionThe aqueous phase is extracted with ethyl ether
  5. customAfter drying
  6. concentrationconcentration, 3.6 g of an oil
  7. customare recovered which
  8. customcrystallizes to a white solid

出典と根拠

ORDレコード
ord-90187e1883424e1999df727823c3ea76
出典データセット
uspto-grants-1994_02
特許番号
US05284838

関連ノート

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