Sodium Hydroxide → 2-Methoxypyridin-4-amine
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][N+:4]=1[O-].[OH-].[Na+]>C(O)(=O)C.[Fe]>[NH2:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 6.3 g of 2-methoxy-4-nitropyridine N-oxide and 12.6 g of iron powder in 150 ml of acetic acid is heated for 1 hour at 100° C. After cooling, sodium hydroxide is added, the mixture is then filtered and the material on the filter is washed with water. The aqueous phase is extracted with ethyl ether. After drying and concentration, 3.6 g of an oil are recovered which crystallizes to a white solid.
後処理
- temperatureAfter cooling
- filtrationthe mixture is then filtered
- washthe material on the filter is washed with water
- extractionThe aqueous phase is extracted with ethyl ether
- customAfter drying
- concentrationconcentration, 3.6 g of an oil
- customare recovered which
- customcrystallizes to a white solid
出典と根拠
- ORDレコード
- ord-90187e1883424e1999df727823c3ea76
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05284838
反応ノート
読み込み中…