Uridine → 5-(3-Aminopropyl)-2'-deoxyuridine
反応式
[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14](=[O:15])[NH:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]1O.[C:18](#[N:21])[CH:19]=[CH2:20]>CO.[Pd]>[NH2:21][CH2:18][CH2:19][CH2:20][C:16]1[C:14](=[O:15])[NH:13][C:11](=[O:12])[N:10]([CH:17]=1)[C@@H:1]1[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[CH2:2]1参加物
5
実験手順
Uridine is reacted with mercuric chloride (5 mmol) at pH 5.0. The 5-mercurichloride-dU so produced is reacted with acrylonitrile and lithium tetrachloro-palladiate in methanol yielding 5-(2-cyanoethenyl) dU which is reduced by hydrogenation at 3 atmospheres in the presence of 10% palladium on charcoal in methanol.
後処理
- customThe 5-mercurichloride-dU so produced
- customyielding 5-(2-cyanoethenyl) dU which
出典と根拠
- ORDレコード
- ord-f68c250589b3464d9b585b7a4ca7feae
- 出典データセット
- uspto-grants-1994_02
- 特許番号
- US05288609
反応ノート
読み込み中…