Ethyl Bromide → Diethyl (3-bromopropyl)phosphonate

反応式

[Br:1][CH2:2][CH2:3][CH2:4]Br.[P:6]([O:13]CC)([O:10][CH2:11][CH3:12])[O:7][CH2:8][CH3:9].BrCC>>[Br:1][CH2:2][CH2:3][CH2:4][P:6]([O:10][CH2:11][CH3:12])(=[O:13])[O:7][CH2:8][CH3:9]

参加物

反応物 3

HCID 6332Ethyl Bromide

HCID 80011,3-Dibromopropane

HCID 31215Triethyl phosphite

生成物 1

HCID 283500Diethyl (3-bromopropyl)phosphonate

反応条件

温度: 130 °C

実験手順

A mixture of 605 g (3.0 mol) of 1,3-dibromopropane and 250 g (1.5 mol) of triethyl phosphite was heated at an oil bath temperature of 130° C., while stirring and passing in nitrogen, for approximately 5 hours until approximately 154 g (1.5 mol) of bromoethane distilled over into a strongly ice-cooled receiver. The reaction mixture was distilled first in a bulb tube and then fractionally.