1-Bromo-3-methylbutane → 7-(3-Methylbutyl)-3-methylxanthine

HRID 2034

反応式

HRID 2034 の反応式
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].[H-].[Na+].[H][H].Br[CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21]>CN(C=O)C.O>[CH3:21][CH:20]([CH3:22])[CH2:19][CH2:18][N:7]1[C:6]2[C:5](=[O:11])[NH:4][C:3](=[O:12])[N:2]([CH3:1])[C:10]=2[N:9]=[CH:8]1

参加物

7

反応物 4

HCID 78911-Bromo-3-methylbutaneHCID 24758Sodium hydrideHCID 706393-MethylxanthineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 196891447-(3-Methylbutyl)-3-methylxanthine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

100 g (0.602 mol) of 3-methylxanthine, dissolved in 1200 ml of DMF, were slowly treated with 16 g (0.66 mol) of sodium hydride. The solution was heated to 60° C. and, when the evolution of hydrogen was at an end, treated with 109 g (0.66 mol) of 1-bromo-3-methylbutane. The reaction mixture was stirred at 100° C. for 12 hours and introduced into 2000 ml of water. The precipitate was filtered off with suction, washed with water and dried to constant weight.

後処理

  1. filtrationThe precipitate was filtered off with suction
  2. washwashed with water
  3. customdried to constant weight

出典と根拠

ORDレコード
ord-53dbbec3515e46f1bf52497ce7ab8115
出典データセット
uspto-grants-1998_03
特許番号
US05728686

関連ノート

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