Iodoethane → HCID 54234050、化合物
反応式
[NH2:1][C@@H:2]([CH2:5][CH:6]([CH3:8])[CH3:7])[CH2:3][SH:4].[H-].[Na+].[CH2:11](I)[CH3:12]>C1COCC1>[NH2:1][C@@H:2]([CH2:5][CH:6]([CH3:8])[CH3:7])[CH2:3][S:4][CH2:11][CH3:12]参加物
5
実験手順
(S)-2-Amino-4-methyl-1-pentanethiol (6.66 g, 50 mmol) is added over 45 minutes to a well stirred slurry of 60% sodium hydride (2.0 g, 50 mmol) in THF (50 mL) at room temperature under N2. After all of the sodium hydride has reacted, a solution of ethyl iodide (4 mL, 50 mmol) in THF (50 mL) is added and the reaction stirred at 20°-25° C. for 18 hours. THF is removed under reduced pressure and the residue partitioned between diethylether and brine. The ether extract is dried (Na2SO4), filtered and concentrated under reduced pressure. Flash chromatograp
後処理
- customTHF is removed under reduced pressure
- customthe residue partitioned between diethylether and brine
- extractionThe ether extract
- dry with materialis dried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-ea3cc594a12c4829b6285a8e058a0629
- 出典データセット
- uspto-grants-1991_05
- 特許番号
- US05019647
反応ノート
読み込み中…