Sodium Hydroxide → Azacycloundecan-2-one

HRID 2054563

反応式

HRID 2054563 の反応式
[C:1]1(=[O:11])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N-:12]=[N+]=[N-].[Na+].[OH-].[Na+]>S(=O)(=O)(O)O.O>[C:1]1(=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:12]1

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 33557Sodium AzideHCID 73918Cyclodecanone

生成物 1

HCID 70523Azacycloundecan-2-one収率 112.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

反応条件

温度
0 °C

実験手順

Cyclodecanone (n=6) (1.0 g) in 10 mL concentrated sulfuric acid was cooled to 0° C. and 0.54 g of sodium azide was added. The reaction continued to stir at 0° C. for 1 h and warmed to room temperature where it was stirred for two h. The solution was diluted with cold water and treated with cold 10% NaOH solution until pH=9. Extraction with ether (2×), drying over magnesium sulfate and evaporation of solvent provided 1.23 g of 2-azacycloundecanone.

後処理

  1. temperaturewarmed to room temperature where it
  2. stirringwas stirred for two h
  3. extractionExtraction with ether (2×)
  4. dry with materialdrying over magnesium sulfate and evaporation of solvent

出典と根拠

ORDレコード
ord-b94c6932bf0b45b18cd81454ddf177d6
出典データセット
uspto-grants-2008_02
特許番号
US07329683B2

関連ノート

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