DL-norvaline → 2-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid

HRID 2065592

反応式

HRID 2065592 の反応式
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH3:16][CH2:17][CH2:18][CH:19]([NH2:23])[C:20]([OH:22])=[O:21].CC#N>O>[C:20]([CH:19]([NH:23][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:18][CH2:17][CH3:16])([OH:22])=[O:21]

参加物

5

反応物 3

HCID 824DL-norvalineHCID 6342AcetonitrileHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

生成物 1

HCID 452568732-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid収率 15%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-2-aminopentanoic acid to provide the title compound in 15% yield as yellow needles (flash chromatography on SiO2, eluent MeCN, H2O, AcOH-20, 1, 0.3).

出典と根拠

ORDレコード
ord-fe506c4b218f493383546404080c7ff9
出典データセット
uspto-grants-2012_10
特許番号
US08288549B2

関連ノート

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