Water → 2-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine

HRID 2073803

反応式

HRID 2073803 の反応式
[NH2:1][C:2]1[C:7]([N:8]=[CH:9][C:10]2[C:15]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:21])=[CH:6][CH:5]=[CH:4][N:3]=1.[BH4-].[Na+].O>CO.C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]2[C:15]([NH:16][C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:21])=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

6

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 144998242-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine

生成物 1

HCID 144998172-Amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine収率 94.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6212Chloroform溶媒

実験手順

To a solution of 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylideneamino)pyridine (229 mg) in methanol (4.6 ml) and chloroform (4.6 ml) was added sodium borohydride (200 mg) and the mixture was stirred for 3.5 hours at room temperature. After water was added, organic layer was separated and dried over magnesium chloride. The solvent was evaporated under reduced pressure. The residue was triturated with diethyl ether to give 2-amino-3-(2-methyl-6-methoxycarbonylaminobenzylamino)pyridine (217 mg).

後処理

  1. customorganic layer was separated
  2. dry with materialdried over magnesium chloride
  3. customThe solvent was evaporated under reduced pressure
  4. customThe residue was triturated with diethyl ether

出典と根拠

ORDレコード
ord-7b8224e273b24a24b6518a7792f389bf
出典データセット
uspto-grants-1990_04
特許番号
US04920129

関連ノート

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