反応式
[CH2:1]([C:3]([N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)([CH2:6][CH3:7])[C:4]#[N:5])[CH3:2].[C:13]1([Li])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[BH4-].[Na+].CC(N1CCCC1)(C)C(N)C1C=CC=CC=1>C(OCCCC)CCC.C1COCC1.CO>[CH2:1]([C:3]([N:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1)([CH2:6][CH3:7])[CH:4]([NH2:5])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:2]参加物
8
反応物 4
生成物 1
試薬・触媒・溶媒 3
実験手順
The title compound (11.5 g, 88%) was prepared from 2-ethyl-2-(1-pyrrolidinyl)butanenitrile D17 (8.8 g, 0.053 mol) and phenyllithium in dibutylether (59 ml of a 1.8M solution; 0.106 mol) in THF (350 ml), followed by reaction with sodium borohydride (3.9 g, 0.103 mol) in methanol (300 ml) in a similar manner to that described in D5. 1H NMR (CDCl3) δ: 0.75 (3H, t), 0.95 (3H, t, J=7.6 Hz), 1.50-1.90 (10H, m), 2.70-2.95 (4H, m), 4.01 (1H, s), 7.19-7.41 (5H, m).
出典と根拠
- ORDレコード
- ord-b04688027dfa4aa1b88601dc5145dfa7
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745642B2
関連ノート
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