Sodium hydride → 2-Ethyl-2-n-propyl-5-methoxy-6,7-dichloro-1-indanone

HRID 2083449ノート

反応式

HRID 2083449 の反応式
[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[C:6]([Cl:15])[C:7]([Cl:14])=[C:8]([O:12][CH3:13])[CH:9]=2)[C:4]1=[O:16])[CH3:2].[H-].[Na+].[CH2:19](I)[CH2:20][CH3:21]>COCCOC>[CH2:1]([C:3]1([CH2:19][CH2:20][CH3:21])[CH2:11][C:10]2[C:5](=[C:6]([Cl:15])[C:7]([Cl:14])=[C:8]([O:12][CH3:13])[CH:9]=2)[C:4]1=[O:16])[CH3:2]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 123955552-Ethyl-5-methoxy-6,7-dichloro-1-indanone

生成物 1

HCID 123955632-Ethyl-2-n-propyl-5-methoxy-6,7-dichloro-1-indanone

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

2-Ethyl-2-n-propyl-5-methoxy-6,7-dichloro-1-indanone is prepared following substantially the same procedure described in Example 5, Step E, using the following substances: 2-ethyl-5-methoxy-6,7-dichloro-1-indanone (13 g., 0.05 mole), sodium hydride (1.3 g., 0.055 mole), 1,2-dimethoxyethane (500 ml.) and n-propyliodide (6 ml.). The above procedure gives 6.0 g. of 2-ethyl-2-n-propyl-5-methoxy-6,7-dichloro-1-indanone which after recrystallization from ethanol melts at 92° C.

後処理

  1. customThe above procedure gives 6.0 g
  2. customof 2-ethyl-2-n-propyl-5-methoxy-6,7-dichloro-1-indanone which after recrystallization from ethanol melts at 92° C.

出典と根拠

ORDレコード
ord-852073325127432f9b6bf861d74cd473
出典データセット
uspto-grants-1978_04
特許番号
US04085219

反応ノート

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