Anthranilic Acid → 5-Chloroisatoic anhydride

HRID 215793

反応式

HRID 215793 の反応式
NC1C=CC=CC=1[C:4](O)=[O:5].[NH2:11][C:12]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:13]=1[C:14]([OH:16])=[O:15].ClC(Cl)(OC(=O)OC(Cl)(Cl)Cl)Cl>C1COCC1>[Cl:21][C:18]1[CH:17]=[C:13]2[C:14]([O:16][C:4](=[O:5])[NH:11][C:12]2=[CH:20][CH:19]=1)=[O:15]

参加物

5

反応物 3

HCID 227Anthranilic AcidHCID 124762-Amino-5-chlorobenzoic acidHCID 94429Triphosgene

生成物 1

HCID 784805-Chloroisatoic anhydride収率 89%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Isatoic anhydrides were prepared from 2-aminobenzoic acid derivatives using the following procedure. A solution of 2-amino-5-chlorobenzoic acid (1.56 g, 9.7 mmol) in 25 mL of dry THF and triphosgene (1.00 g, 3.3 mmol) was stirred at room temperature for 18 h. The resultant solid was filtered, washed with cold acetone, and dried under vacuum to give 1.56 g (89%) of 5-chloroisatoic anhydride.

後処理

  1. filtrationThe resultant solid was filtered
  2. washwashed with cold acetone
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-33d43fc23d5f47c2a0646fa1bb768808
出典データセット
uspto-grants-2012_06
特許番号
US08193185B2

関連ノート

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