反応式
[Cl:1][C:2]1[CH:20]=[C:19]([C:21]2[O:22][CH2:23][CH2:24][N:25]=2)[CH:18]=[C:17]([Cl:26])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([CH2:15][OH:16])[CH:11]=1.[H-].[Na+].[H][H].[CH3:31]I>O1CCCC1.CCOCC>[Cl:26][C:17]1[CH:18]=[C:19]([C:21]2[O:22][CH2:23][CH2:24][N:25]=2)[CH:20]=[C:2]([Cl:1])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[O:14][N:13]=[C:12]([CH2:15][O:16][CH3:31])[CH:11]=1参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
To a solution of 6.8 g of 5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-isoxazolemethanol (Example 116) in 100 ml of dry tetrahydrofuran was added 0.45 g of sodium hydride. After hydrogen evolution had ceased, the solution was cooled in an ice-bath and 1.1 ml of methyl iodide was added. The reaction mixture was stirred at room temperature for 48 hrs, then diluted with ether and washed well with water. Evaporation of the solvent and chromatography provided 3.1 g of the product as a viscous yellow oil.
後処理
- temperaturethe solution was cooled in an ice-bath
- washwashed well with water
- customEvaporation of the solvent and chromatography
出典と根拠
- ORDレコード
- ord-7b59cc9c13994e77a7b216e958479b03
- 出典データセット
- uspto-grants-1990_07
- 特許番号
- US04939267
関連ノート
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