Water → p-((1-Oxoallyl)amino)benzoic acid

HRID 2178185

反応式

HRID 2178185 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[C:11](Cl)(=[O:14])[CH:12]=[CH2:13].O>CN(C=O)C.N1C=CC=CC=1>[C:11]([NH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)(=[O:14])[CH:12]=[CH2:13]

参加物

6

反応物 3

HCID 962WaterHCID 9784-Aminobenzoic AcidHCID 13140Acryloyl chloride

生成物 1

HCID 84866p-((1-Oxoallyl)amino)benzoic acid収率 94.2%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of 4-aminobenzoic acid (1.40 g, 10 mmol) in DMF (10 mL) and pyridine (0.5 ml) was cooled to 0° C. To this solution was added of acryloyl chloride (0.94 g, 10 mmol) and the resulting mixture was stirred for 3 hours. The mixture was poured into 200 ml of water and the white solid obtained was filtered, washed with water and ether. Drying under high vacuum provided 1.8 g of the desired product which was used in the next step without purification.

後処理

  1. customthe white solid obtained
  2. filtrationwas filtered
  3. washwashed with water and ether
  4. customDrying under high vacuum

出典と根拠

ORDレコード
ord-8471144d668d4d5e888fb6ff29bf7a75
出典データセット
uspto-grants-2015_06
特許番号
US09067929B2

関連ノート

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