Tetrahydrofuran → 2-(4-Methylbutyloxy)acetaldehyde diethylacetal

HRID 21889

反応式

HRID 21889 の反応式
C[C@H:2]([OH:6])[CH2:3][CH2:4][CH3:5].[H-].[Na+].[CH2:9]([O:11][CH:12]([O:15][CH2:16][CH3:17])[CH2:13]Br)[CH3:10].O1CCC[CH2:19]1>>[CH2:9]([O:11][CH:12]([O:15][CH2:16][CH3:17])[CH2:13][O:6][CH2:2][CH2:3][CH2:4][CH2:5][CH3:19])[CH3:10]

参加物

5

反応物 4

HCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 2724896(+)-2-Pentanol

生成物 1

HCID 199306252-(4-Methylbutyloxy)acetaldehyde diethylacetal

実験手順

35 g of (S)-2-pentanol was dissolved in tetrahydrofuran, and 16 g of 60% sodium hydride was added thereto. After stirring for 30 minutes, 80 g of bromoacetaldehyde diethylacetal was added thereto, and the mixture was refluxed for 6 hours. After the reaction solution were concentrated and water and ether was added thereto, the mixture was shaken for mixing. The organic layer was collected and was dried with magnesium sulfate to remove the solvent off. Purification was carried out by column chromatography to obtain 2-(4-methylbutyloxy)acetaldehyde diethylacetal (54).

後処理

  1. temperaturethe mixture was refluxed for 6 hours
  2. concentrationAfter the reaction solution were concentrated
  3. additionwater and ether was added
  4. stirringthe mixture was shaken
  5. additionfor mixing
  6. customThe organic layer was collected
  7. dry with materialwas dried with magnesium sulfate
  8. customto remove the solvent off
  9. customPurification

出典と根拠

ORDレコード
ord-2eb3063371754bbd90900474ffe7d134
出典データセット
uspto-grants-1995_06
特許番号
US05425897

関連ノート

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