Triethylamine → 2-bromo-N-pyridin-2-yl-acetamide
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.CCN(CC)CC.[Br:15][CH2:16][C:17](Br)=[O:18]>C1COCC1>[Br:15][CH2:16][C:17]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1)=[O:18]参加物
5
実験手順
To a solution of 2-aminopyridine (48.8 mmol) in anhydrous THF (98 mL) at room temperature was added Et3N (58.6 mmol) and bromoacetyl bromide (58.6 mmol) dropwise The mixture was stirred overnight and quenched with sat. NaHCO3 (aq). EtOAc was added to the mixture and the layers separated. The aqueous phase was extracted with EtOAc and the combined organics dried (MgSO4) and concentrated in vacuo to a brown solid.
後処理
- customquenched with sat. NaHCO3 (aq)
- additionEtOAc was added to the mixture
- customthe layers separated
- extractionThe aqueous phase was extracted with EtOAc
- dry with materialthe combined organics dried (MgSO4)
- concentrationconcentrated in vacuo to a brown solid
出典と根拠
- ORDレコード
- ord-6549214e493a46aa947896b6d4871768
- 出典データセット
- uspto-grants-2012_12
- 特許番号
- US08329729B2
反応ノート
読み込み中…