Ethyl Acetate → Methyl 2-amino-3-methoxybenzoate
反応式
[CH3:1][O:2][C:3]1[C:4]([N+:13]([O-])=O)=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].CCOC(C)=O>C1COCC1.CO.[Pd]>[NH2:13][C:4]1[C:3]([O:2][CH3:1])=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]参加物
6
実験手順
A suspension of compound 52 (26.2 g, 124 mmol) and Pd/C (10 wt. %, 6.0 g) in THF (400 mL) and MeOH (200 mL) was stirred under an atmosphere of H2 at room temperature for 18 hours. EtOAc (300 mL) was added to the mixture and filtered through a Celite pad. The filtrate was concentrated in vacuo to provide the crude product 53 (22.4 g, 99%) as colorless oil.
後処理
- filtrationfiltered through a Celite pad
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-f29ead4b9b4b443baed769dc2288e81c
- 出典データセット
- uspto-grants-2016_06
- 特許番号
- US09371303B2
反応ノート
読み込み中…