Benzyl Alcohol → Dibenzyl ether

HRID 22157

反応式

HRID 22157 の反応式
[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]1([CH3:19])[CH:14]=[CH:13][C:12](S(O)(=O)=O)=[CH:11][CH:10]=1>O1CCCC1.CN(C)C=O>[CH2:1]([O:8][CH2:19][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 244Benzyl AlcoholHCID 6101p-Toluenesulfonic acid

生成物 1

HCID 7657Dibenzyl ether

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

In a manner similar to that described in Example I, 0.68 ml of benzyl alcohol and 7 mg of p-toluenesulfonic acid are added to a solution of 350 mg of Compound Z-1(DMTD) in a mixture of 7 ml of tetrahydrofuran and 3 ml of dimethylformamide and the mixture stirred at room temperature for 24 hours. At the end the volatiles are removed in vacuo to obtain a residue which is purified on a preparative HPLC column using water/acetonitrile (40/60) as eluant. The appropriate fractions are combined and lyophilized to obtain benzyl ether of Z-1(DMTD).

後処理

  1. customAt the end the volatiles are removed in vacuo
  2. customto obtain a residue which
  3. customis purified on a preparative HPLC column

出典と根拠

ORDレコード
ord-1454dbbd4a4c45a6b9416b9307ef6d28
出典データセット
uspto-grants-1995_06
特許番号
US05428009

関連ノート

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