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Hydrochloric Acid → HCID 57684406、化合物

HRID 2249658
ノート
印刷プレビュー

反応式

HRID 2249658 の反応式
[CH2:1]([N:6]1[C:10]2[CH:11]=[CH:12][C:13]([C:15]([C:17]3[CH:18]=[CH:19][C:20]([O:32][CH2:33][CH2:34][CH:35]([CH3:37])[CH3:36])=[C:21]([CH2:23][C:24]([O:26]CCC(C)C)=[O:25])[CH:22]=3)=[O:16])=[CH:14][C:9]=2[N:8]([CH2:38][CH2:39][CH:40]([CH3:42])[CH3:41])[C:7]1=[O:43])[CH2:2][CH:3]([CH3:5])[CH3:4].[OH-].[Na+].O.Cl>C(O)C.O1CCCC1.C(Cl)(Cl)Cl>[CH2:1]([N:6]1[C:10]2[CH:11]=[CH:12][C:13]([C:15]([C:17]3[CH:18]=[CH:19][C:20]([O:32][CH2:33][CH2:34][CH:35]([CH3:36])[CH3:37])=[C:21]([CH2:23][C:24]([OH:26])=[O:25])[CH:22]=3)=[O:16])=[CH:14][C:9]=2[N:8]([CH2:38][CH2:39][CH:40]([CH3:42])[CH3:41])[C:7]1=[O:43])[CH2:2][CH:3]([CH3:4])[CH3:5]
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68984731HCID 68984731、化合物

生成物 1

HCID 57684406HCID 57684406、化合物収率 85.1%

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒
HCID 6212
Chloroform
溶媒
HCID 8028Tetrahydrofuran溶媒

実験手順

In a mixture of 3 ml of ethanol and 3 ml of tetrahydrofuran is dissolved 0.28 g of isopentyl 2-[5-[(1,3-diisopentyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)carbonyl]-2-(isopentyloxy)phenyl]acetate. After adding 1.4 ml of 1 mol/L sodium hydroxide solution, the mixture is stirred at ambient temperature for 3 hours. Water and chloroform are added to the reaction mixture, pH is adjusted to 2 with 2 mol/L hydrochloric acid, and the organic layer is separated. The organic layer thus obtained is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. Thus, 0.21 g of 2-[5-[(1,3-diisopentyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)carbonyl]-2-(isopentyloxy)phenyl]-acetic acid is obtained as a white foaming product.

後処理

  1. customthe organic layer is separated
  2. customThe organic layer thus obtained
  3. washis washed with water and saturated aqueous solution of sodium chloride successively
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-9754e52e568041f0b5a0e33ff0b90c90
出典データセット
uspto-grants-2008_01
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07314888B1

反応ノート

読み込み中…

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