Diethyl Ether → 9b-Allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline

HRID 224969

反応式

HRID 224969 の反応式
[CH2:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[CH:6]=[CH:5][C:4]=2[NH:3][CH2:2]1.[C:14]1(C([O-])=C([N+]([O-])=O)C=[C:19]([N+]([O-])=O)[CH:18]=1)[N+]([O-])=O.C1([C:44]([OH:45])=C([N+]([O-])=O)C=C([N+]([O-])=O)C=1)[N+]([O-])=O.[OH-].[Li+].[CH3:48]COCC>C(O)C>[CH2:19]([C:9]12[C:8]3[CH:10]=[C:11]([O:45][CH3:44])[CH:12]=[CH:13][C:7]=3[CH2:6][CH:5]=[C:4]1[N:3]([CH3:48])[CH2:2][CH2:1]2)[CH:18]=[CH2:14]

参加物

7

反応物 5

HCID 3283Diethyl EtherHCID 3939Lithium HydroxideHCID 6954Picric AcidHCID 4432340Picrate3 回HCID 111479652,3-Dihydro-1h-benzo[e]indole

生成物 1

HCID 233307809b-Allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The benz[e]indoline IIa was regenerated from the picrate XIVd (X=picric acid) as follows: A mixture of finely powder picrate (10 mmol), 1 N aqueous lithium hydroxide (50 ml), ethanol (20 ml) and ether (100 ml) in a separatory funnel was shaken until all the picrate had dissolved. The ether phase was washed with water and, after drying, was evaporated to dryness to give the free base IIa quantitatively.

後処理

  1. dissolutionhad dissolved
  2. washThe ether phase was washed with water
  3. customafter drying
  4. customwas evaporated to dryness
  5. customto give the free base IIa quantitatively

出典と根拠

ORDレコード
ord-2a59832b8cf3466b9a85bdd208afeaee
出典データセット
uspto-grants-1980_11
特許番号
US04234731

関連ノート

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