Sodium Iodide → HCID 57722476、化合物

HRID 2267098ノート

反応式

HRID 2267098 の反応式
[I-].[Na+].Cl[Si](C)(C)[CH3:5].[CH2:8]([O:15][C:16]1[C:21]([C:22](=[O:32])[NH:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)=[CH:20][N:19]=[C:18]([C:33]([O:35][CH3:36])=[O:34])[C:17]=1[O:37][CH3:38])[C:9]1C=CC=CC=1.S([O-])(O)=O.[Na+]>C(#N)C>[CH3:17][C:16]([CH3:21])=[O:15].[CH:16]([O:15][CH:8]([CH3:9])[CH3:5])([CH3:17])[CH3:21].[F:31][C:28]1[CH:27]=[CH:26][C:25]([CH2:24][NH:23][C:22]([C:21]2[C:16](=[O:15])[C:17]([O:37][CH3:38])=[C:18]([C:33]([O:35][CH3:36])=[O:34])[NH:19][CH:20]=2)=[O:32])=[CH:30][CH:29]=1

参加物

7

反応物 4

HCID 5238Sodium IodideHCID 6397ChlorotrimethylsilaneHCID 23665763Sodium BisulfiteHCID 57722482HCID 57722482、化合物

生成物 2

HCID 22221350Acetone diisopropyl etherHCID 57722476HCID 57722476、化合物収率 253.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a suspension of sodium iodide (5.51 g, 36.8 mmol) in acetonitrile (50 ml) was added chlorotrimethylsilane (4.66 ml, 36.8 mmol), and the mixture was stirred at room temperature for 10 minutes. After to this solution was added the compound 27 (2.60 g, 6.13 mmol) under ice-cooling, this was stirred at the same temperature for 20 minutes. To the reaction solution was added a 5% sodium hydrogen sulfite solution, followed by extraction with ethyl acetate. The extract was washed with an aqueous saturated sodium bicarbonate solution and an aqueous saturated sodium chlorite solution, and dried with anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting solid matter was recrystallized to obtain (acetone-diisopropyl ether) and methyl 5-(4-fluorobenzylcarbamoyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate 28 (1.73 g, 84%) as a colorless crystal.

後処理

  1. temperaturecooling
  2. stirringthis was stirred at the same temperature for 20 minutes
  3. extractionfollowed by extraction with ethyl acetate
  4. washThe extract was washed with an aqueous saturated sodium bicarbonate solution
  5. dry with materialan aqueous saturated sodium chlorite solution, and dried with anhydrous sodium sulfate
  6. distillationThe solvent was distilled off under reduced pressure
  7. customthe resulting solid matter was recrystallized

出典と根拠

ORDレコード
ord-56b0008966e14ed8a11781408ffc0463
出典データセット
uspto-grants-2010_12
特許番号
US07858788B2

反応ノート

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