2-Amino-4-methylpyrimidine → cyclohexyl-[7-methyl-2-(1-methyl-1H-pyrrol-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-amine

HRID 22815

反応式

HRID 22815 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[CH:9]1([N+:15]#[C-:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.[CH3:17][N:18]1[CH:22]=[CH:21][CH:20]=[C:19]1[CH:23]=O>Cl(O)(=O)(=O)=O>[CH:9]1([NH:15][C:16]2[N:3]3[CH:4]=[CH:5][C:6]([CH3:8])=[N:7][C:2]3=[N:1][C:23]=2[C:19]2[N:18]([CH3:17])[CH:22]=[CH:21][CH:20]=2)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

参加物

5

反応物 3

HCID 79392-Amino-4-methylpyrimidineHCID 145041-Methyl-1H-pyrrole-2-carbaldehydeHCID 79129Cyclohexyl isocyanide

生成物 1

HCID 22591929cyclohexyl-[7-methyl-2-(1-methyl-1H-pyrrol-2-yl)-imidazo[1,2-a]pyrimidin-3-yl]-amine

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Compound (38) was prepared according to the general synthesis instructions from 1.0 ml of 2-amino-4-methylpyrimidine solution (0.1 M, DCM), 0.575 ml of cyclohexyl isocyanide solution (0.2 M, DCM), 0.500 ml of N-methylpyrrole-2-carbaldehyde solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%).

出典と根拠

ORDレコード
ord-9a13c14e378f4b7cabd9e4ac51904452
出典データセット
uspto-grants-2005_02
特許番号
US06849642B2

関連ノート

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