1-(4-aminobutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine → 1-(4-aminobutyl)-2-propyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-4-amine

HRID 2283839

反応式

HRID 2283839 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[N:7]([CH2:20][CH2:21][CH3:22])[N:8]=[C:9]2[C:18]=1[C:17]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:11]=[C:10]2[NH2:19]>FC(F)(F)C(O)=O.C(Cl)(Cl)Cl.CO.[Pt](=O)=O>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[N:7]([CH2:20][CH2:21][CH3:22])[N:8]=[C:9]2[C:18]=1[C:17]1[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=1[N:11]=[C:10]2[NH2:19]

参加物

6

反応物 1

HCID 577175771-(4-aminobutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine

生成物 1

HCID 577176321-(4-aminobutyl)-2-propyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-4-amine

試薬・触媒・溶媒 4

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒HCID 6212Chloroform溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 1-(4-aminobutyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine (2.40 g, 8.06 mmol) in trifluoroacetic acid (20 mL) was treated with platinum (IV) oxide. The mixture was hydrogenated on a Parr apparatus at 50 psi (3.5×105 Pa) for 1 day, and then was diluted with chloroform (50 mL) and methanol (25 mL). The mixture was filtered through CELITE filter agent. The filtrate was concentrated under reduced pressure to yield 6.0 g the bis-trifluoroacetic acid salt of 1-(4-aminobutyl)-2-propyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-c]quinolin-4-amine in residual trifluoroacetic acid as a yellow liquid.

後処理

  1. filtrationThe mixture was filtered through CELITE
  2. filtrationfilter agent
  3. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5110b30809ff48be9094585a4497e2f4
出典データセット
uspto-grants-2015_09
特許番号
US09145410B2

関連ノート

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