Water → 1-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one

HRID 234493

反応式

HRID 234493 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[C:17](OC(=O)C)(=[O:19])[CH3:18].O>C(Cl)(Cl)Cl>[C:17]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1)(=[O:19])[CH3:18]

参加物

6

反応物 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 10328Indoline

生成物 1

HCID 276731-(2,3-Dihydro-1H-indol-1-yl)ethan-1-one

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒3 回

実験手順

A solution of 11.9 g of indoline in 100 ml of chloroform is cooled to 0° C., 13.9 ml of triethylamine are added and a solution of 10.4 ml of acetic anhydride in 10 ml of chloroform is then added dropwise, followed by 0.1 g of 4-dimethylaminopyride. After stirring for two hours at RT, water is added to the reaction mixture, extraction is carried out with chloroform, the organic phase is dried over sodium sulfate and the solvent is evaporated off under vacuum to give 15.44 g of the expected product, which is used as such.

後処理

  1. dry with materialthe organic phase is dried over sodium sulfate
  2. customthe solvent is evaporated off under vacuum

出典と根拠

ORDレコード
ord-f6e181a0f676489494226c2a8c4f58a6
出典データセット
uspto-grants-1997_01
特許番号
US05594023

関連ノート

読み込み中…