Sodium Hydroxide → 7-Fluoro-2,3-dihydro-1H-indole

HRID 2353458

反応式

HRID 2353458 の反応式
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.C([BH3-])#N.[Na+].[OH-].[Na+]>C(O)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH2:8][CH2:7]2

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 27745047-Fluoro-1H-indoleHCID 5003444Sodium cyanoborohydride

生成物 1

HCID 167682617-Fluoro-2,3-dihydro-1H-indole収率 54.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

7-fluoroindole (2.0 g, 14.8 mmol) was dissolved in acetic acid (6 mL) and sodium cyanoborohydride (1.87 g, 29.6 mmol) was added in 5 portions. The mixture was stirred for 1 hour then poured into 150 mL of 2N NaOH. The mixture was extracted with methylene chloride. The organics were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated to give 7-fluoroindoline (1.1 g).

後処理

  1. extractionThe mixture was extracted with methylene chloride
  2. washwashed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-74bf08cac423424aa246f19a619d4605
出典データセット
uspto-grants-2010_07
特許番号
US07750038B2

関連ノート

読み込み中…